Clopidogrel
mode of action
Clopidogrel (INN)(trade name Plavix) is an oral, thienopyridine class antiplatelet agent used to
inhibit blood clots in coronary artery
disease,peripheral vascular
disease, and cerebrovascular disease.
Action
The drug works by irreversibly
inhibiting a receptor called P2Y12, an adenosine
diphosphate (ADP)
chemoreceptor on platelet cell membranes.
Adverse effects
Adverse effects include hemorrhage, severe neutropenia, and thrombotic
thrombocytopenic purpura (TTP).
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