/daɪˈæzɨpæm/), first marketed as Valium ( /ˈvæliəm/) byHoffmann-La Roche, is a benzodiazepine drug. Diazepam is also marketed in Australia as Antenex.It is commonly used for treating anxiety, insomnia, seizuresincluding status epilepticus, muscle spasms (such as in cases of tetanus),restless legs syndrome, alcohol withdrawal, benzodiazepine withdrawal andMénière's disease.
Adverse effects
Adverse effects of diazepam include anterograde amnesia (especially at higher doses) and sedation, as well as paradoxical effects such as excitement, rage or worsening of seizures in epileptics.
Benzodiazepines also can cause or worsendepression.
Long-term effects of benzodiazepines such as diazepam include tolerance, benzodiazepine dependence and benzodiazepine withdrawal syndrome upon dose reduction; additionally, after cessation of benzodiazepines, cognitivedeficits may persist for at least six months and may not fully return to normal; however, it was suggested that longer than six months may be needed for recovery from some deficits.[4]
Diazepam also has physical dependence potential and can cause serious problems of physical dependence with long term use.
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